Anethum graveolens Prevents Liver and Kidney Injury, Oxidative Stress and Inflammation in Mice Exposed to Nicotine Perinatally
نویسندگان
چکیده
Perinatal exposure to nicotine imbalances the redox status in newborns. This study investigated effect of Anethum graveolens (dill) extract on oxidative stress and tissue injury liver kidney mice newborns exposed perinatally. Pregnant received (0.25 mg/kg) gestational day 12 5 after birth and/or A. 1 15 birth. Newborn showed multiple histopathological alterations liver, including inflammatory cell infiltration degenerative changes. Nicotine increased hepatic renal reactive oxygen species (ROS), lipid peroxidation, tumor necrosis factor (TNF-α), interleukin-6 (IL-6) inducible nitric oxide synthase (iNOS) (p < 0.001), decreased antioxidant defenses 0.001). supplementation significantly prevented injury, suppressed ROS generation peroxidation 0.001) response enhanced defenses. In addition, upregulated Nrf2 HO-1 mRNA activity normal nicotine-exposed mice. conclusion, protects against perinatal nicotine-induced stress, inflammation newborn Nrf2/HO-1 signaling
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ژورنال
عنوان ژورنال: Coatings
سال: 2021
ISSN: ['2079-6412']
DOI: https://doi.org/10.3390/coatings11070838